Sharma, PrernaShah, KajalLoomba, JohannaPatel, ArtiMallawaarachchi, IndikaBlazek, OliviaRatcliffe, SarahBreathett, KhadijahJohnson, Amber E.Taylor, Angela M.Salerno, MichaelRagosta, MichaelSodhi, NishthaAddison, DanielMohammed, SelmaBilchick, Kenneth C.Mazimba, Sula2024-10-182024-10-182022Sharma P, Shah K, Loomba J, et al. The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy. Clin Cardiol. 2022;45(10):1070-1078. doi:10.1002/clc.23908https://hdl.handle.net/1805/44060Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p = .001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p = .024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p = .001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.en-USAttribution 4.0 InternationalCOVID-19Cardiac catheterizationPediatric clinical cardiologyPercutaneous coronary interventionArticle