Sey, Michael S. L.Schmaltz, LeslieAl-Haddad, Mohammad A.DeWitt, John M.Calley, Cynthia S. J.Juan, MichelleLasisi, FemiSherman, StuartMcHenry, LeeImperiale, Thomas F.LeBlanc, Julia K.2019-04-232019-04-232015-02Sey, M. S. L., Schmaltz, L., Al-Haddad, M. A., DeWitt, J. M., Calley, C. S. J., Juan, M., … LeBlanc, J. K. (2015). Effectiveness and safety of serial endoscopic ultrasound–guided celiac plexus block for chronic pancreatitis. Endoscopy International Open, 3(1), E56–E59. https://doi.org/10.1055/s-0034-13779192364-3722https://hdl.handle.net/1805/18930Background and study aims: Endoscopic ultrasound – guided celiac plexus block (EUS-CPB) is an established treatment for pain in patients with chronic pancreatitis (CP), but the effectiveness and safety of repeated procedures are unknown. Our objective is to report our experience of repeated EUS-CPB procedures within a single patient. , Patients and methods: A prospectively maintained EUS database was retrospectively analyzed to identify patients who had undergone more than one EUS-CPB procedure over a 17-year period. The main outcome measures included number of EUS-CPB procedures for each patient, self-reported pain relief, duration of pain relief, and procedure-related adverse events. , Results: A total of 248 patients underwent more than one EUS-CPB procedure and were included in our study. Patients with known or suspected CP (N = 248) underwent a mean (SD) of 3.1 (1.6) EUS-CPB procedures. In 76 % of the patients with CP, the median (range) duration of the response to the first EUS-CPB procedure was 10 (1 – 54) weeks. Lack of pain relief after the initial EUS-CPB was associated with failure of the next EUS-CPB (OR 0.17, 95 %CI 0.06 – 0.54). Older age at first EUS-CPB and pain relief after the first EUS-CPB were significantly associated with pain relief after subsequent blocks (P = 0.026 and P = 0.002, respectively). Adverse events included peri-procedural hypoxia (n = 2) and hypotension (n = 1) and post-procedural orthostasis (n = 2) and diarrhea (n = 4). No major adverse events occurred., Conclusions: Repeated EUS-CPB procedures in a single patient appear to be safe. Response to the first EUS-CPB is associated with response to subsequent blocks.en-USPublisher PolicyAttribution-NonCommercial-NoDerivs 3.0 United Statesendoscopic ultrasoundchronic pancreatitisceliac plexus blockArticle