Weiss, Michael A.2024-12-092024-12-092024-11-11Weiss MA. Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance. Nat Commun. 2024;15(1):9744. Published 2024 Nov 11. doi:10.1038/s41467-024-54006-6https://hdl.handle.net/1805/44847Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalInsulinProtein stabilityPharmacologyArticle