Shew, Marcia L.Ermel, Aaron C.Weaver, Bree A.Tong, YanTu, WanzhuKester, Laura M.Denski, CherylFortenberry, J. DennisBrown, Darron R.2015-09-152015-09-152013-11Shew, M. L., Ermel, A. C., Weaver, B. A., Tong, Y., Tu, W., Kester, L. M., … Brown, D. R. (2013). Association of Chlamydia trachomatis Infection With Redetection of Human Papillomavirus After Apparent Clearance. The Journal of Infectious Diseases, 208(9), 1416–1421. http://doi.org/10.1093/infdis/jit346https://hdl.handle.net/1805/6945BACKGROUND: Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection. METHODS: For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections. RESULTS: A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78). CONCLUSIONS: This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.en-USPublisher PolicyHPV redetectionChlamydiaHuman papillomavirusArticle