Bin Alamer, OthmanPalmisciano, PaoloRowe, Scott E.Gupta, Aditya DuttaHaider, MaryamAlduhaymi, MohammedCohen-Gadol, Aaron A.Yu, KennyEl-Ahmadieh, Tarek Y.Haider, Ali S.2023-10-262023-10-262022Bin Alamer O, Palmisciano P, Rowe SE, et al. Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes. Anticancer Res. 2022;42(3):1189-1198. doi:10.21873/anticanres.15585https://hdl.handle.net/1805/36700Background/aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. Materials and methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Results: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. Conclusion: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.en-USPublisher PolicyPineal region gliomaGliomaPineal region tumorsSystematic reviewArticle