Foxa, Gabrielle E.Turner, Lisa M.Robling, Alexander G.Yang, TaoWilliams, Bart O.2022-07-062022-07-062021Foxa GE, Liu Y, Turner LM, Robling AG, Yang T, Williams BO. Generation and Characterization of Mouse Models for Skeletal Disease. Methods Mol Biol. 2021;2221:165-191. doi:10.1007/978-1-0716-0989-7_11https://hdl.handle.net/1805/29505Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that induce symptoms modeling OA. Here, we will describe protocols outlining the induction of experimental OA in mice as well as detailed descriptions of methods for analyzing skeletal phenotypes using micro-computerized tomography and skeletal histomorphometry.en-USPublisher PolicyHistomorphometryOsteoarthritismicroCTArticle