Grahame, Nicholas J.2020-01-022020-01-022000Grahame N. J. (2000). Selected lines and inbred strains. Tools in the hunt for the genes involved in alcoholism. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 24(3), 159–163.https://hdl.handle.net/1805/21691In their quest to elucidate the genetic influences contributing to alcoholism, researchers have long used selected lines and inbred strains of rodents. Selected lines are obtained by repeatedly mating those animals within a population that show extremely high or low values of the desired trait. Inbred strains are generated by mating male and female siblings, irrespective of any particular trait, over several generations. Both of these approaches have provided researchers with extensive knowledge about the genetic and neurobiological mechanisms contributing to alcohol-related traits. However, the use of these models is associated with some limitations, mostly resulting from the inbreeding involved in generating such lines and strains. Nevertheless, these models can offer some advantages over other genetic approaches, such as the analysis of quantitative trait loci or the generation of transgenic and knockout mice.en-USPublisher PolicyAnimal modelAnimal strainsAnimal selectively bred for AOD (alcohol or other drug) preferenceSelective breedingGenetic theory of AODU (AOD use, abuse, and dependence)PhenotypeQuantitative trait locusGene knockout technologyTransgenic technologyArticle