Wang, HaiAgarwal, PranayLiang, YutongXu, JiangshengZhao, GangTkaczuk, Katherine H. R.Lu, XiongbinHe, Xiaoming2018-08-312018-08-312018-10Wang, H., Agarwal, P., Liang, Y., Xu, J., Zhao, G., Tkaczuk, K. H. R., … He, X. (2018). Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled with one nanoplatform. Biomaterials. https://doi.org/10.1016/j.biomaterials.2018.07.021https://hdl.handle.net/1805/17275Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or electromagnetic field. More recently, cryosurgery (also called cryotherapy and cryoablation), destruction of diseased tissues by first cooling/freezing and then warming back, has been used to treat various diseases including cancer in the clinic. Here we developed a cold-responsive nanoparticle for controlled drug release as a result of the irreversible disassembly of the nanoparticle when cooled to below ∼10 °C. Furthermore, this nanoparticle can be used to generate localized heating under near infrared (NIR) laser irradiation, which can facilitate the warming process after cooling/freezing during cryosurgery. Indeed, the combination of this cold-responsive nanoparticle with ice cooling and NIR laser irradiation can greatly augment cancer destruction both in vitro and in vivo with no evident systemic toxicity.enPublisher Policycold-responsiveNIPAMPLGAArticle