Broxmeyer, Hal E.2019-10-122019-10-122018-08-01Broxmeyer H. E. (2018). Enhancement of stem cell engraftment on a WHIM. The Journal of clinical investigation, 128(8), 3240–3242. doi:10.1172/JCI121857https://hdl.handle.net/1805/21142WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a genetic autoimmune disorder that results from gain-of-function mutations in the gene encoding chemokine receptor CXCR4. A previous study characterized a patient with WHIM who underwent a chromothriptic event that resulted in spontaneous deletion of the WHIM allele in a single hematopoietic stem cell and subsequent cure of the disease. In this issue of the JCI, Gao et al. extend this work and show that Cxcl4-haplosufficient bone marrow has a selective advantage for long-term engraftment in murine WHIM models. Moreover, successful engraftment occurred without prior conditioning of recipients. Together, these results have important implications for improving hematopoietic stem/progenitor cell transplant not only for patients with WHIM but also for all patients who may require the procedure.en-USAgammaglobulinemiaBone Marrow TransplantationImmunologic Deficiency SyndromesReceptors, CXCR4Article