Korc, Murray2016-08-262016-08-262015-04-01Korc, M. (2015). Pancreatic Cancer–Associated Diabetes Is an “Exosomopathy.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 21(7), 1508–1510. http://doi.org/10.1158/1078-0432.CCR-14-29901078-0432https://hdl.handle.net/1805/10778Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.en-USPublisher PolicyAdrenomedullinmetabolismDiabetes MellitusetiologyExosomesInsulin-Secreting CellsPancreatic NeoplasmscomplicationsArticle