Desai, Ankit A.Machado, Roberto F.Cohen, Robyn T.2024-02-082024-02-082022Desai AA, Machado RF, Cohen RT. The Cardiopulmonary Complications of Sickle Cell Disease. Hematol Oncol Clin North Am. 2022;36(6):1217-1237. doi:10.1016/j.hoc.2022.07.014https://hdl.handle.net/1805/38338Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with extensive morbidity and early mortality. While there have been recent improvements in available disease-modifying therapies for SCD, cardiopulmonary complications remain a major risk factor for death in this population. We provide an overview of current knowledge regarding several of the major acute and chronic cardiopulmonary complications in SCD, including: acute chest syndrome, airway disease, lung function abnormalities, nocturnal hypoxemia and sleep disordered breathing, pulmonary vascular disease, and sickle cell cardiomyopathy.en-USPublisher PolicyAcute chest syndromeLung functionPulmonary hypertensionSickle cell cardiomyopathySickle cell diseaseSleep-disordered breathingArticle