Wright, Christian S.Zhou, JingSayer, R. DrewKim, Jung EunCampbell, Wayne W.2019-05-102019-05-102018-07-23Wright, C. S., Zhou, J., Sayer, R. D., Kim, J. E., & Campbell, W. W. (2018). Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial. Nutrients, 10(7), 946. doi:10.3390/nu10070946https://hdl.handle.net/1805/19232Age-related increases in intermuscular adipose tissue (IMAT) impair muscle quality, decrease functional capacity, and promote several cardiometabolic and inflammatory disorders. Whether these age-related alterations in muscle composition improve by consuming a high-protein (HP) diet with whole eggs are unclear. This parallel-design, randomized-controlled trial assessed the effects of a 12-week eucaloric HP diet with three whole eggs per day (1.4 g protein kg-1 day-1) versus a normal-protein diet void of eggs (NP, 0.8 g protein kg-1 day-1) on muscle composition (IMAT), cardiometabolic health, and systemic inflammation in older adults with overweight or obesity (12 men and 10 women; age 70 ± 5 years, BMI 31.3 ± 3.2 kg/m², mean ± SD). No changes in muscle composition were observed over time, independent of protein intake. Total body weight was reduced in both groups (-3.3 ± 1.2%) and lean mass was preserved only with the HP diet. LDL concentration and hip circumference decreased only with the NP diet, while MCP-1 and HsCRP concentrations increased over time in both groups. A HP diet with whole eggs promotes lean mass retention with modest weight loss, but does not positively influence muscle composition, cardiometabolic health or systemic inflammation, compared to a NP diet void of eggs.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesDietary proteinEggsDiet compositionSkeletal muscle compositionIntermuscular adipose tissueInflammationArticle