Wang, TingGreen, Linden A.Gupta, Samir K.Amet, TohtiByrd, Daniel J.Yu, QiguiTwigg, Homer L.Clauss, Matthias2016-03-312016-03-312014-07-25Wang, T., Green, L. A., Gupta, S. K., Amet, T., Byrd, D. J., Yu, Q., … Clauss, M. (2014). Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients. AIDS Research and Human Retroviruses, 31(2), 217–220. http://doi.org/10.1089/aid.2013.0250https://hdl.handle.net/1805/9158We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.en-USPublisher PolicyBloodVirologyHIV InfectionsLeukocytes, MononuclearArticle