Harper, Jonathan D.Metzler, IanHall, Michael KennedyChen, Tony T.Maxwell, Adam D.Cunitz, Bryan W.Dunmire, BarbrinaThiel, JeffWilliams, James C., Jr.Bailey, Michael R.Sorensen, Mathew D.2023-06-142023-06-142021Harper JD, Metzler I, Hall MK, et al. First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies. J Endourol. 2021;35(4):506-511. doi:10.1089/end.2020.0725https://hdl.handle.net/1805/33745Purpose: To test the effectiveness (Participant A) and tolerability (Participant B) of urinary stone comminution in the first-in-human trial of a new technology, burst-wave lithotripsy (BWL). Materials and Methods: An investigational BWL and ultrasonic propulsion system was used to target a 7-mm kidney stone in the operating room before ureteroscopy (Participant A). The same system was used to target a 7.5 mm ureterovesical junction stone in clinic without anesthesia (Participant B). Results: For Participant A, a ureteroscope inserted after 9 minutes of BWL observed fragmentation of the stone to <2 mm fragments. Participant B tolerated the procedure without pain from BWL, required no anesthesia, and passed the stone on day 15. Conclusions: The first-in-human tests of BWL pulses were successful in that a renal stone was comminuted in <10 minutes, and BWL was also tolerated by an awake subject for a distal ureteral stone.en-USAttribution-NonCommercial 4.0 InternationalBurst wave lithotripsyCalculiLithotripsyPhysicsShock wave lithotripsyUltrasoundUrolithiasisArticle