Sen, Chandan K.Roy, Sashwati2023-07-102023-07-102021Sen CK, Roy S. The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure. J Invest Dermatol. 2021;141(6):1382-1385. doi:10.1016/j.jid.2020.11.021https://hdl.handle.net/1805/34251Iterative cycles of epithelial-mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of barrier function of the repaired skin is a hallmark of functional wound closure. Both EMT and MET are subject to control by glycemic status. New work in this issue supports the notion that hyperglycemia blunts epithelial plasticity.en-USPublisher PolicyEpithelial-mesenchymal transitionHyperglycemiaSkinStifleArticle