Comer, Brian S.2016-05-062016-05-062015-11Comer, B. S. (2015). Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer? Drug Development Research, 76(7), 354–356. http://doi.org/10.1002/ddr.21276https://hdl.handle.net/1805/9543MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammation. Inhibition of miR-155 or COX-2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR-155 may be a promising target for antagonizing COX-2 expression in colorectal and other cancers.enPublisher PolicyBICPTGS-2MicroRNA-155cancerArticle