Atallah-Yunes, Suheil AlbertRobertson, Michael J.2023-06-152023-06-152022-04-28Atallah-Yunes SA, Robertson MJ. Current and emerging monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies in treatment of lymphoma. Leuk Res Rep. 2022;17:100319. Published 2022 Apr 28. doi:10.1016/j.lrr.2022.100319https://hdl.handle.net/1805/33781The improvement in outcomes seen with the introduction of rituximab, a CD20 monoclonal antibody in combination with chemotherapy or as a single agent in the treatment of indolent non-Hodgkin lymphomas has paved the way for development of various forms of monoclonal antibodies that act in different ways against non-Hodgkin lymphoma tumor cells. These could directly target a single surface antigen resulting in various ways of tumor cells toxicity and killing. Other forms of monoclonal antibodies include antibody-drug conjugates and bispecific antibodies. The role of therapeutic monoclonal antibodies in the treatment of lymphoma will be reviewed, highlighting their mode of action, clinical efficacy, and side effects.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalLymphomaImmunotherapyMonoclonal antibodiesAntibody drug conjugatesBispecific antibodiesArticle