Jiang, JiePavlova, Natalya N.Zhang, Ji2019-08-052019-08-052018-04-11Jiang, J., Pavlova, N. N., & Zhang, J. (2018). Asparagine, a critical limiting metabolite during glutamine starvation. Molecular & cellular oncology, 5(3), e1441633. doi:10.1080/23723556.2018.1441633https://hdl.handle.net/1805/20176A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesGlutamineAsparagineAsparaginaseGlutamine synthetaseProtein synthesisBiology of malignant cellsMechanisms of oncogenesis and tumor progressionNovel therapeutic targetsOncogenes and tumor suppressor genesTumor metabolismArticle