Kays, Joshua K.Sohn, Jeffrey D.Kim, Bradford J.Goze, KatherineKoniaris, Leonidas G.2019-07-052019-07-052018-11-15Kays, J. K., Sohn, J. D., Kim, B. J., Goze, K., & Koniaris, L. G. (2018). Approach to wild-type gastrointestinal stromal tumors. Translational gastroenterology and hepatology, 3, 92. doi:10.21037/tgh.2018.10.13https://hdl.handle.net/1805/19840Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. WT-GIST arises most commonly due to underlying alternate proliferative signals associated with germ-line, genetic mutations. WT-GIST frequently arises in patients with BRAF mutations, Carney’s Triad or neurofibromatosis type-1 (NF-1). All patients with WT-GIST require a careful examination for germ-line mutations and very close observation for recurrent tumors. Surgery remains a mainstay therapy for these patients. This review aims to discuss the most recent data available on the diagnosis and treatment of WT-GIST.en-USGastrointestinal stromal tumor (GIST)SarcomaSuccinate dehydrogenase (SDH)Wild-type gastrointestinal stromal tumor (WT-GIST)Article