Miao, JinminYang, KeKurek, MartinGe, Haibo2016-02-262016-02-262015-07Miao, J., Yang, K., Kurek, M., & Ge, H. (2015). Palladium-Catalyzed Site-Selective Fluorination of Unactivated C (sp3)–H Bonds. Organic letters, 17(15), 3738-3741.https://hdl.handle.net/1805/8521The transition-metal-catalyzed direct C–H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C–H functionalization, site-selective fluorination of unactivated sp3 carbons remains a challenge. Direct, highly site-selective and diastereoselective fluorination of aliphatic amides via a palladium-catalyzed bidentate ligand-directed C–H bond functionalization process on unactivated sp3 carbons is reported. With this approach, a wide variety of β-fluorinated amino acid derivatives and aliphatic amides, important motifs in medicinal and agricultural chemistry, were prepared with palladium acetate as the catalyst and Selectfluor as the fluorine source.en-USAttribution-NonCommercial 3.0 United Statesfluorine substitutionC−H bond fluorinationArticle