Xie, JingwuZhang, Xiaoli2017-06-132017-06-132016-01-20Xie, J., & Zhang, X. (2016). The Impact of Genomic Profiling for Novel Cancer Therapy– Recent Progrss in Non-Small Cell Lung Cancer. Journal of Genetics and Genomics = Yi Chuan Xue Bao, 43(1), 3–10. http://doi.org/10.1016/j.jgg.2015.09.003https://hdl.handle.net/1805/12988There is high expectation for significant improvements in cancer patient care after completion of the human genome project in 2003. Through pains-taking analyses of genomic profiles in cancer patients, a number of targetable gene alterations have been discovered, with some leading to novel therapies, such as activating mutations of EGFR, BRAF and ALK gene fusions. As a result, clinical management of cancer through targeted therapy has finally become a reality for a subset of cancers, such as lung adenocarcinomas and melanomas. In this review, we summarize how gene mutation discovery leads to new treatment strategies using non-small cell lung cancer (NSCLC) as an example. We also discuss possible future implications of cancer genome analyses.en-USPublisher PolicyGene mutationLung cancerTargeted therapyEGFRALKArticle