Yang, KemingLi, XinZeleznik, Oana A.Eliassen, A. HeatherClish, Clary B.Cho, EunyoungSomani, Ally-Khan B.Qureshi, Abrar A.Giovannucci, Edward L.Nan, Hongmei2021-02-252021-02-252021Yang, K., Li, X., Zeleznik, O. A., Eliassen, A. H., Clish, C. B., Cho, E., Somani, A.-K. B., Qureshi, A. A., Giovannucci, E. L., & Nan, H. (2021). Higher susceptibility to sunburn is associated with decreased plasma glutamine and increased plasma glutamate levels among US women: An analysis of the Nurses’ Health Study I and II. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2020.12.081https://hdl.handle.net/1805/25287To the Editor: The metabolism of glutamine and glutamate, 2 important amino acids synthesized in the human body, may have an etiologic role in melanoma, an aggressive skin malignancy. 1 , 2 Preclinical experiments and clinical trials have found that metabotropic glutamate receptor 1 blocker and glutamate release inhibitor (eg, Riluzole) can suppress melanoma cell migration, invasion, and proliferation. 2 Additionally, inhibiting glutaminase, the enzyme that converts glutamine to glutamate, further reduced glutamate bioavailability and suppressed tumor progression. 1 Susceptibility to sunburn, a pigmentary trait, is a well-known risk factor for melanoma. 3 However, it is unclear whether plasma glutamate and glutamine are affected by this host factor even before cancer onset.enPublisher Policysunburnplasma glutamineplasma glutamateArticle