Romanoski, Casey E.Qi, XinshuaiSangam, ShreyaVanderpool, Rebecca R.Stearman, Robert S.Conklin, AustinGonzalez-Garay, ManuelRischard, FranzAyon, Ramon J.Wang, JianSimonson, TatumBabicheva, AleksandraShi, YinanTang, HaiyangMakino, AyakoKanthi, YogendraGeraci, Mark W.Garcia, Joe G.N.Yuan, Jason X.-J.Desai, Ankit A.2022-04-222022-04-222020-12-07Romanoski CE, Qi X, Sangam S, et al. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020;10(4):2045894020968531. Published 2020 Dec 7. doi:10.1177/2045894020968531https://hdl.handle.net/1805/28708Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.en-USAttribution-NonCommercial 4.0 InternationalPBMCRNAseqPulmonary arterial hypertensionTranscriptome profilingArticle