Guerrero, DanielDzemidzic, MarioMoghaddam, MahdiLiu, MintaoAvena-Koenigsberger, AndreaHarezlak, JaroslawKareken, David A.Plawecki, Martin H.Cyders, Melissa A.Goñi, Joaquín2025-05-132025-05-132025-04-08Guerrero D, Dzemidzic M, Moghaddam M, et al. Resting State Functional Connectivity Patterns Associate with Alcohol Use Disorder Characteristics: Insights from the Triple Network Model. Preprint. ArXiv. 2025;arXiv:2504.06199v1. Published 2025 Apr 8.https://hdl.handle.net/1805/48001Prolonged alcohol use results in neuroadaptations that mark more severe and treatment-resistant alcohol use. The goal of this study was to identify functional connectivity brain patterns underlying Alcohol Use Disorder (AUD)-related characteristics in fifty-five adults (31 female) who endorsed heavy alcohol use. We hypothesized that resting-state functional connectivity (rsFC) of the Salience (SN), Frontoparietal (FPN), and Default Mode (DMN) networks would reflect self-reported recent and lifetime alcohol use, laboratory-based alcohol seeking, urgency, and sociodemographic characteristics related to AUD. To test our hypothesis, we combined the triple network model (TNM) of psychopathology with a multivariate data-driven approach, regularized partial least squares (rPLS), to unfold concurrent functional connectivity (FC) patterns and their association with AUD characteristics. We observed three concurrent associations of interest: i) drinking and age-related cross communication between the SN and both the FPN and DMN; ii) family history density of AUD and urgency anticorrelations between the SN and FPN; and iii) alcohol seeking and sex-associated SN and DMN interactions. These findings demonstrate the utility of combining theory- and data-driven approaches to uncover associations between resting-state functional substrates and AUD-related characteristics that could aid in the identification, development, and testing of novel treatment targets across preclinical and clinical models.en-USAttribution 4.0 InternationalProlonged alcohol useNeuroadaptationsAlcohol use disorder (AUD)Article