Burns, Sarah S.Kapur, Reuben2023-10-162023-10-162022Burns SS, Kapur R. Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells. Cell Stem Cell. 2022;29(8):1156-1158. doi:10.1016/j.stem.2022.07.002https://hdl.handle.net/1805/36310In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes the notion that the cumulative inflammatory events over the course of an organism's lifespan may irreversibly damage LT-HSCs.en-USPublisher PolicyAgingHematopoietic stem cellsInflammationArticle