Roberts, W. EugeneMangum, Jonathan E.Schneider, Paul M.2024-05-012024-05-012022Roberts WE, Mangum JE, Schneider PM. Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection. Curr Osteoporos Rep. 2022;20(1):106-119. doi:10.1007/s11914-022-00723-0https://hdl.handle.net/1805/40407Purpose of review: Compare noninfectious (part I) to infectious (part II) demineralization of bones and teeth. Evaluate similarities and differences in the expression of hard tissue degradation for the two most common chronic demineralization diseases: osteoporosis and dental caries. Recent findings: The physiology of demineralization is similar for the sterile skeleton compared to the septic dentition. Superimposing the pathologic variable of infection reveals a unique pathophysiology for dental caries. Mineralized tissues are compromised by microdamage, demineralization, and infection. Osseous tissues remodel (turnover) to maintain structural integrity, but the heavily loaded dentition does not turnover so it is ultimately at risk of collapse. A carious tooth is a potential vector for periapical infection that may be life-threatening. Insipient caries is initiated as a subsurface decalcification in enamel that is not detectable until a depth of ~400μm when it becomes visible as a white spot. Reliable detection and remineralization of invisible caries would advance cost-effective wellness worldwide.en-USAttribution 4.0 InternationalCost-effectiveHealthcareWellnessDental cariesWhite spot lesionRemineralizationArticle