Williams, ImadeO’Malley, MatthewDeHart, HaddieWalker, BobbyUlhaskumar, VrushabhJothirajah, PranavRay, HaimantiLandrum, Lisa M.Delaney, Joe R.Nephew, Kenneth P.Carpenter, Richard L.2025-03-242025-03-242025Williams I, O'Malley M, DeHart H, et al. MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer. Cancer Res Commun. 2025;5(2):253-266. doi:10.1158/2767-9764.CRC-24-0400https://hdl.handle.net/1805/46512We show that HSF1 and MYC genes are co-amplified in more than 30% of HGSOC and demonstrate that HSF1 and MYC functionally cooperate to drive the growth of HGSOC cells. This work provides the foundation for HSF1 and MYC co-amplification as a biomarker for treatment efficacy of the polo-like kinase 1 inhibitor volasertib in HGSOC.en-USAttribution 4.0 InternationalCell cycle proteinsHeat shock transcription factorsProtein kinase inhibitorsProto-oncogene proteinsOvarian neoplasmsArticle