Nakhostin-Ansari, AminZimet, Gregory D.Khonji, Mohammad SaeidAghajani, FaezehTeymourzadeh, AzinKazerooni, Amir Ali RastegarPirayandeh, PendarAghajani, ReyhanehSafari, SepidehKhalaj, KamandMemari, Amir Hossein2023-06-162023-06-162022-04-23Nakhostin-Ansari A, Zimet GD, Khonji MS, et al. Acceptance or Rejection of the COVID-19 Vaccine: A Study on Iranian People's Opinions toward the COVID-19 Vaccine. Vaccines (Basel). 2022;10(5):670. Published 2022 Apr 23. doi:10.3390/vaccines10050670https://hdl.handle.net/1805/33822We aimed to assess the Iranian people’s attitude and confidence in the COVID-19 vaccine, their concerns about the safety of vaccines, and their reasons for accepting or rejecting the COVID-19 vaccine. We conducted a web-based cross-sectional study with a mixed qualitative−quantitative approach from December 2020 to February 2021. Our questionnaire consisted of a COVID-19 vaccine attitude questionnaire, a COVID-19 vaccine confidence inventory, a modified vaccine safety scale, and questions about participants’ decision to accept or refuse the COVID-19 vaccine, and their explanations for their decisions. The research included 1928 people with an average age of 34.88 years with 1236 (64.1%) being female. A total of 1330 participants desired to have the COVID-19 vaccine (69%). Female gender, lower educational levels, following COVID-19 news through sources other than websites and social media, not following COVID-19 news, and loss of a first-degree relative due to COVID-19 were all associated with a more negative attitude toward the COVID-19 vaccine (p < 0.01). To conclude, the acceptance rate of the COVID-19 vaccine among Iranians is comparable to the international average; however, it is still unfavorable. There are serious challenges to the vaccination program in Iran, such as older adults’ lower intention to undergo the COVID-19 vaccine and misinformation.en-USAttribution 4.0 InternationalCOVID-19AttitudeSafetyVaccineArticle