Smith, Aaron T.Livingston, Meredith R.Mai, AntonelloFiletici, PatriziaQueener, Sherry F.Sullivan, William J., Jr.2024-08-292024-08-292007Smith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ Jr. Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii. Antimicrob Agents Chemother. 2007;51(3):1109-1111. doi:10.1128/AAC.01256-06https://hdl.handle.net/1805/43036We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.en-USPublisher PolicyAntiprotozoal agentsEnzyme inhibitorsHistone acetyltransferasesOrganellesQuinolinesSaccharomyces cerevisiaeToxoplasmaArticle