Bilateral Central Giant Cell Granulomas of the Mandible in An Eight Year-Old Girl with Noonan Syndrome (Noonan-Like/Multiple Giant Cell Lesions Syndrome)

Edwards, Paul C.Fox, JoyceFantasia, John EGoldberg, JeffKelsch, Robert D2014-06-052014-06-052005-03Edwards, P. C., Fox, J., Fantasia, J. E., Goldberg, J., & Kelsch, R. D. (2005). Bilateral central giant cell granulomas of the mandible in an 8-year-old girl with Noonan syndrome (Noonan-like/multiple giant cell lesion syndrome). Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 99(3), 334-340.https://hdl.handle.net/1805/4500A number of conditions can present with lesions that histologically are indistinguishable from the central giant cell granuloma (CGCG) of bone, including brown tumors of hyperparathyroidism, cherubism, and, less commonly, a number of inherited syndromes. We report a case of an eight-year girl who presented with bilateral CGCGs of the posterior mandible. Characteristic facial features, reported increased post-operative bleeding and history of pulmonary stenosis led us to suspect a diagnosis of Noonan syndrome. A medical geneticist confirmed this on further evaluation. This case report will discuss the salient features of this diagnosis.en-UScentral giant cell granulomaNoonan syndromeBilateral Central Giant Cell Granulomas of the Mandible in An Eight Year-Old Girl with Noonan Syndrome (Noonan-Like/Multiple Giant Cell Lesions Syndrome)Article