Lu, XinJin, Eun-JungCheng, XiFeng, ShanShang, XiaoyingDeng, PingnaJiang, ShanChang, QingRahmy, SharifChaudhary, SeemaLu, XueminZhao, RenWang, Y. AlanDePinho, Ronald A.2019-01-312019-01-312017-12-01Lu, X., Jin, E. J., Cheng, X., Feng, S., Shang, X., Deng, P., Jiang, S., Chang, Q., Rahmy, S., Chaudhary, S., Lu, X., Zhao, R., Wang, Y. A., … DePinho, R. A. (2017). Opposing roles of TGFβ and BMP signaling in prostate cancer development. Genes & development, 31(23-24), 2337-2342.https://hdl.handle.net/1805/18290SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression. These analyses reveal the complexity of TGFβ-BMP signaling and illuminate potential therapeutic targets for prostate cancer.en-USAttribution-NonCommercial 3.0 United StatesBMPR2PTENSMAD4TGFBR2Bone metastasisProstate cancerArticle