Wang, ChenkunGao, SujuanHendrie, Hugh C.Kesterson, JoeCampbell, Noll L.Shekhar, AnanthaCallahan, Christopher M.2017-11-172017-11-172016-04Wang, C., Gao, S., Hendrie, H. C., Kesterson, J., Campbell, N. L., Shekhar, A., & Callahan, C. M. (2016). Antidepressant use in the elderly is associated with an increased risk of dementia. Alzheimer Disease and Associated Disorders, 30(2), 99–104. http://doi.org/10.1097/WAD.00000000000001031546-4156https://hdl.handle.net/1805/14614A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on antidepressants but depressed, and not on antidepressants and not depressed. SSRI and non-SSRI users had significantly higher dementia risk than the nondepressed nonusers (hazard ratio [HR]=1.83, P=0.0025 for SSRI users and HR=1.50, P=0.004 for non-SSRI users). In addition, SSRIs users had significantly higher dementia risk than non-users with severe depression (HR=2.26, P=0.0005). Future research is needed to confirm our results in other populations and to explore potential mechanism underlying the observed association.en-USPublisher PolicyAntidepressantsDementiaRetrospective cohort studyArticle