Bhojani, NaeemBidair, MohamedZorn, Kevin C.Trainer, AndrewArther, AndrewKramolowsky, EugeneDoumanian, LeoElterman, DeanKaufman, Ronald P.Lingeman, JamesKrambeck, AmyEure, GreggBadlani, GopalPlante, MarkUchio, EdwardGin, GregGoldenberg, LarryPaterson, RyanSo, AlanHumphreys, MitchKaplan, StevenMotola, JayDesai, MihirRoehrborn, Claus2020-12-232020-12-232019-07Bhojani, N., Bidair, M., Zorn, K. C., Trainer, A., Arther, A., Kramolowsky, E., Doumanian, L., Elterman, D., Kaufman, R. P., Lingeman, J., Krambeck, A., Eure, G., Badlani, G., Plante, M., Uchio, E., Gin, G., Goldenberg, L., Paterson, R., So, A., … Roehrborn, C. (2019). Aquablation for Benign Prostatic Hyperplasia in Large Prostates (80-150 cc): 1-Year Results. Urology, 129, 1–7. https://doi.org/10.1016/j.urology.2019.04.029https://hdl.handle.net/1805/24739OBJECTIVE To report 12-month safety and effectiveness outcomes of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume prostates. METHODS One hundred and one men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent a robotic-assisted Aquablation procedure in a prospective multicenter international clinical trial. Functional and safety outcomes were assessed at 12 months postoperatively. RESULTS Mean prostate volume was 107 cc (range 80-150). Mean operative time was 37 minutes and mean Aquablation resection time was 8 minutes. The average length of hospital stay following the procedure was 1.6 days. Mean International Prostate Symptom Score improved from 23.2 at baseline to 6.2 at 12 months (P <.0001). Mean International Prostate Symptom Score quality of life improved from 4.6 at baseline to 1.3 at 12-month follow-up (P <.0001). Significant improvements were seen in Qmax (12-month improvement of 12.5 cc/sec) and postvoid residual (drop of 171 cc in those with postvoid residual >100 at baseline). Antegrade ejaculation was maintained in 81% of sexually active men. No patient underwent a repeat procedure for BPH symptoms. There was a 2% de novo incontinence rate at 12 months, and 10 patients did require a transfusion postoperatively while 5 required take back fulgurations. At 12 months, prostate-specific antigen reduced from 7.1 ± 5.9 ng/mL at baseline to 4.4 ± 4.3 ng/mL. CONCLUSION The Aquablation procedure is demonstrated to be safe and effective in treating men with large prostates (80-150 cc) after 1 year of follow-up, with an acceptable complication rate and without a significant increase in procedure or resection time compared to smaller sized glands.enAttribution-NonCommercial-NoDerivatives 4.0 InternationalAquablationbenign prostatic hyperplasialarge-volume prostatesArticle