Kumar, Raj G.Ketchum, Jessica M.Hammond, Flora M.Novack, Thomas A.O’Neil-Pirozzi, Therese M.Silva, Marc A.Dams-O’Connor, Kristen2023-07-122023-07-122022Kumar RG, Ketchum JM, Hammond FM, et al. Health and cognition among adults with and without Traumatic Brain Injury: A matched case-control study. Brain Inj. 2022;36(3):415-423. doi:10.1080/02699052.2022.2034190https://hdl.handle.net/1805/34312Objectives: To evaluate associations between traumatic brain injury (TBI) and presence of health conditions, and to compare associations of health and cognition between TBI cases and controls. Methods: This matched case-control study used data from the TBI Model Systems National Database (TBI cases) and Midlife in the United States II and Refresher studies (controls). 248 TBI cases were age-, sex-, race-, and education-matched without replacement to three controls. Cases and controls were compared on prevalence of 18 self-reported conditions, self-rated health, composite scores from the Brief Test of Adult Cognition by Telephone. Results: The following conditions were significantly more prevalent among TBI cases versus controls: anxiety/depression (OR = 3.12, 95% CI: 2.20, 4.43, p < .001), chronic sleeping problems (OR = 2.76, 95% CI: 1.86, 4.10, p < .001), headache/migraine (OR = 2.61, 95% CI: 1.50, 4.54, p = .0007), and stroke (OR = 6.42, 95% CI: 2.93, 14.10, p < .001). The relationship between self-rated health and cognition significantly varied by TBI (pinteraction = 0.002). Conclusion: Individuals with TBI have greater odds of selected neurobehavioral conditions compared to their demographically similar uninjured peers. Among persons with TBI there was a stronger association between poorer self-rated health and cognition than controls. TBI is increasingly conceptualized as a chronic disease; current findings suggest post-TBI health management requires cognitive supports.en-USPublisher PolicyTraumatic brain injuriesCognitionDiseaseHealthArticle