Simon, Jeremy M.Parker, Joel S.Liu, FengRothbart, Scott B.Ait-Si-Ali, SlimaneStrahl, Brian D.Jin, JianDavis, Ian J.Mosley, Amber L.Pattenden, Samantha G.2016-12-152016-12-152015-10-23Simon, J. M., Parker, J. S., Liu, F., Rothbart, S. B., Ait-Si-Ali, S., Strahl, B. D., … Pattenden, S. G. (2015). A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. The Journal of Biological Chemistry, 290(43), 26088–26102. http://doi.org/10.1074/jbc.M115.6544590021-9258 1083-351Xhttps://hdl.handle.net/1805/11624Background: G9a-GLP lysine methyltransferases mono- and di-methylate histone H3 lysine 9 (H3K9me2).Results: Widely interspaced zinc finger (WIZ) regulates H3K9me2 levels through a mechanism that involves retention of G9a on chromatin.Conclusion: The G9a-GLP-WIZ complex has unique functions when bound to chromatin that are independent of the H3K9me2 mark.Significance: Combining pharmacologic and genetic manipulations is essential to any translational hypotheses related to G9a function.en-USPublisher's Policychromatin modificationchromatin regulationprotein methylationtranscriptiontranscription coregulatorArticle