Fritz, Brandon M.Boehm II, Stephen L.2017-06-202017-06-202016-02-04Fritz, B. M., & Boehm, S. L. (2016). Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 65, 297–308. http://doi.org/10.1016/j.pnpbp.2015.05.012https://hdl.handle.net/1805/13124Binge ethanol consumption has widespread negative consequences for global public health. Rodent models offer exceptional power to explore the neurobiology underlying and affected by binge-like drinking as well as target potential prevention, intervention, and treatment strategies. An important characteristic of these models is their ability to consistently produce pharmacologically-relevant blood ethanol concentration. This review examines the current available rodent models of voluntary, pre-dependent binge-like ethanol consumption and their utility in various research strategies. Studies have demonstrated that a diverse array of neurotransmitters regulate binge-like drinking, resembling some findings from other drinking models. Furthermore, repeated binge-like drinking recruits neuroadaptive mechanisms in mesolimbocortical reward circuitry. New opportunities that these models offer in the current context of mechanistic research are also discussed.en-USPublisher PolicyAlcoholLimited-accessMiceBingeNeurobiologyArticle