Castellsagué, XavierAult, Kevin A.Bosch, F. XavierBrown, DarronCuzick, JackFerris, Daron G.Jours, Elmar A.Garland, Suzanne M.Giuliano, Anna R.Hernandez-Avila, MauricioHuh, WarnerIversen, Ole-ErikKjaer, Susanne K.Luna, JoaquinMonsonego, JosephMuñoz, NubiaMyers, EvanPaavonen, JormaPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredLuxembourg, AlainSings, Heather L.Velicer, Christine2016-11-022016-11-022016-12Castellsagué, X., Ault, K. A., Bosch, F. X., Brown, D., Cuzick, J., Ferris, D. G., ... & Huh, W. (2016). Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region. Papillomavirus Research, 2, 61-69.https://hdl.handle.net/1805/11333Background We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region Methods Women ages 15–26 and 24–45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81–85%). Types 31/33/45/52/58 accounted for 25–30% of CIN1 in Latin America and Europe, but 14–18% in North America and Asia. Types 31/33/45/52/58 accounted for 33–38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17–18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2–11% of CIN2/3. Conclusions The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3.enAttribution-NonCommercial-NoDerivs 3.0 United Stateshuman papillomaviruscervical cancercervical intraepithelial neoplasiaArticle