Wang, BanSingh, JujharDeng, Yongming2024-06-122024-06-122023Wang B, Singh J, Deng Y. Photoredox-Catalyzed Divergent Radical Cascade Annulations of 1,6-Enynes via Pyridine N-Oxide-Promoted Vinyl Radical Generation. Org Lett. 2023;25(51):9219-9224. doi:10.1021/acs.orglett.3c03930https://hdl.handle.net/1805/41463The divergent organophotoredox-catalyzed radical cascade annulation reactions of 1,6-enynes were developed. A series of cyclopropane-fused hetero- and carbo-bicyclic, tricyclic, and spiro-tetracyclic compounds were facilely synthesized from a broad scope of 1,6-enynes and 2,6-lutidine N-oxide under mild and metal-free conditions with blue light-emitting diode light irradiation. The cascade annulation reaction occurs with the intermediacy of a β-oxyvinyl radical, which is produced from photocatalytically generated pyridine N-oxy radical addition to the carbon-carbon triple bond.en-USPublisher Policy1,6-enynesCarbon-carbon triple bondCascade annulationArticle