Griffin, Ashley C.He, LuSunjaya, Anthony P.King, Andrew J.Khan, ZubinNwadiugwu, MartinDouthit, BrianSubbian, VigneshNguyen, VietBraunstein, MarkJaffe, CharlesSchleyer, Titus2023-09-182023-09-182022-10-12Griffin AC, He L, Sunjaya AP, et al. Clinical, technical, and implementation characteristics of real-world health applications using FHIR. JAMIA Open. 2022;5(4):ooac077. Published 2022 Oct 12. doi:10.1093/jamiaopen/ooac077https://hdl.handle.net/1805/35595Objective: Understanding the current state of real-world Fast Healthcare Interoperability Resources (FHIR) applications (apps) will benefit biomedical research and clinical care and facilitate advancement of the standard. This study aimed to provide a preliminary assessment of these apps' clinical, technical, and implementation characteristics. Materials and methods: We searched public repositories for potentially eligible FHIR apps and surveyed app implementers and other stakeholders. Results: Of the 112 apps surveyed, most focused on clinical care (74) or research (45); were implemented across multiple sites (56); and used SMART-on-FHIR (55) and FHIR version R4 (69). Apps were primarily stand-alone web-based (67) or electronic health record (EHR)-embedded (51), although 49 were not listed in an EHR app gallery. Discussion: Though limited in scope, our results show FHIR apps encompass various domains and characteristics. Conclusion: As FHIR use expands, this study-one of the first to characterize FHIR apps at large-highlights the need for systematic, comprehensive methods to assess their characteristics.en-USAttribution 4.0 InternationalFast healthcare interoperability resourcesApplication programming interfaceHealth information interoperabilityMedical informaticsArticle