Abu-Sultaneh, SamerIyer, Narayan PrabhuFernández, AnalíaGaies, MichaelGonzález-Dambrauskas, SebastiánHotz, Justin ChristianKneyber, Martin C.J.López-Fernández, Yolanda M.Rotta, Alexandre T.Werho, David K.Baranwal, Arun KumarBlackwood, BronaghCraven, Hannah J.Curley, Martha A.Q.Essouri, SandrineFioretto, Jose RobertoHartmann, Silvia M.M.Jouvet, PhilippeKorang, Steven KwasiRafferty, Gerrard F.Ramnarayan, PadmanabhanRose, LouiseTume, Lyvonne N.Whipple, Elizabeth C.Wong, Judith Ju MingEmeriaud, GuillaumeMastropietro, Christopher W.Napolitano, NatalieNewth, Christopher J.L.Khemani, Robinder G.2022-12-212022-12-212022-12-20Abu-Sultaneh S, Iyer NP, Fernández A, Gaies M, González-Dambrauskas S, Hotz JC, Kneyber MCJ, López-Fernández YM, Rotta AT, Werho DK, Baranwal AK, Blackwood B, Craven HJ, Curley MAQ, Essouri S, Fioretto JR, Hartmann SM, Jouvet P, Korang SK, Rafferty GF, Ramnarayan P, Rose L, Tume LN, Whipple EC, Wong JJM, Emeriaud G, Mastropietro CW, Napolitano N, Newth CJL, Khemani RG, On behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Operational Definitions related to Pediatric Ventilator Liberation, CHEST (2023), doi: https://doi.org/10.1016/j.chest.2022.12.010.https://hdl.handle.net/1805/30786BACKGROUND: Common, operational definitions are crucial to assess interventions and outcomes related to pediatric mechanical ventilation. These definitions can reduce unnecessary variability amongst research and quality improvement efforts, to ensure findings are generalizable and can be pooled to establish best practices. RESEARCH QUESTION: Can we establish operational definitions for key elements related to pediatric ventilator liberation using a combination of detailed literature review and consensus-based approaches? STUDY DESIGN AND METHODS: A panel of 26 international experts in pediatric ventilator liberation, two methodologists and two librarians conducted systematic reviews on eight topic areas related to pediatric ventilator liberation. Through a series of virtual meetings, we established draft definitions which were voted upon using an anonymous web-based process. Definitions were revised by incorporating extracted data gathered during the systematic review and discussed in another consensus meeting. A second round of voting was conducted to confirm the final definitions. RESULTS: In eight topic areas identified by the experts, 16 preliminary definitions were established. Based on initial discussion and the first round of voting, modifications were suggested for 11 of the 16 definitions. There was significant variability in how these items were defined in the literature reviewed. The final round of voting achieved ≥80% agreement for all 16 definitions in the following areas: what constitutes respiratory support (invasive mechanical ventilation and non-invasive respiratory support), liberation and failed attempts to liberate from invasive mechanical ventilation, liberation from respiratory support, duration of non-invasive respiratory support, total duration of invasive mechanical ventilation, spontaneous breathing trials, extubation readiness testing, 28-ventilator free days, and planned vs rescue use of post-extubation non-invasive respiratory support. INTERPRETATION: We propose these consensus-based definitions for elements of pediatric ventilator liberation, informed by evidence, be used for future quality improvement initiatives and research studies to improve generalizability, and facilitate comparison.en-USAttribution-NonCommercial-NoDerivatives 4.0 Internationalairway extubationextubation failurehigh flow nasal cannulamechanical ventilationnoninvasive ventilationpediatric intensive care unitsventilator weaningArticle