Jomha, MohammedDabboussi, TarekParker, Noah P.Manchanda, ShaliniChernyak, YelenaStahl, Stephanie M.2023-11-172023-11-172022-10Jomha, M., Dabboussi, T., Parker, N. P., Manchanda, S., Chernyak, Y., & Stahl, S. M. (2022). Prevalence of insomnia and restless legs syndrome in patients with upper airway stimulation therapy and effects on treatment outcomes. Sleep Medicine, 98, 121–126. https://doi.org/10.1016/j.sleep.2022.06.016https://hdl.handle.net/1805/37110Objective This study aims to explore the prevalence of insomnia and restless legs syndrome (RLS) and the possible effects of these conditions on treatment adherence and outcomes in patients with upper airway stimulation (UAS) therapy for the treatment of obstructive sleep apnea. Methods Consecutive patients who underwent UAS system implantation were retrospectively studied. Patients without insomnia or RLS, insomnia, RLS, and both insomnia and RLS were compared. The apnea-hypopnea index (AHI), in-lab UAS titration data, Epworth Sleepiness Scale (ESS), and adherence to UAS therapy were compared. Results Sixty-four patients who had UAS implantation and completed post-implant in-lab UAS titration were identified. Insomnia was present in 47%, RLS in 28%, and both insomnia and RLS in 14%. During in-lab titration, the AHI improved for all groups and did not differ across groups. The arousal index on in-lab titration was higher in patients with both RLS and insomnia compared to those without these conditions. At the time of the in-lab titration, the hours of UAS therapy usage were reduced for patients with RLS (4.7 ± 1.9 h/night, p = 0.027) compared to those without RLS (6.0 ± 2.0 h/night). The ESS was higher in patients with RLS compared to those without RLS at in-lab titration. Conclusion Insomnia and RLS are common in patients using UAS therapy. A decrease in UAS usage and higher ESS were present in patients with RLS. Further research evaluating the long-term effects of insomnia and RLS in UAS therapy usage and benefit is needed.en-USPublisher Policyhypoglossal nerve stimulationinsomniaobstructive sleep apnea (OSA)prevalencerestless legs syndrome (RLS)upper airway stimulation (UAS)Article