Umberfield, Elizabeth E.Kardia, Sharon L. R.Jiang, YunThomer, Andrea K.Harris, Marcelline R.2024-02-212024-02-212022Umberfield EE, Kardia SLR, Jiang Y, Thomer AK, Harris MR. Regulations and Norms for Reuse of Residual Clinical Biospecimens and Health Data. West J Nurs Res. 2022;44(11):1068-1081. doi:10.1177/01939459211029296https://hdl.handle.net/1805/38578Nurse scientists are increasingly interested in conducting secondary research using real world collections of biospecimens and health data. The purposes of this scoping review were to (1) identify federal regulations and norms that bear authority or give guidance over reuse of residual clinical biospecimens and health data, (2) summarize domain experts’ interpretations of permissions of such reuse, and (3) summarize key issues for interpreting regulations and norms. Final analysis included 25 manuscripts and 23 regulations and norms. This review illustrates contextual complexity for reusing residual clinical biospecimens and health data, and explores issues such as privacy, confidentiality, and deriving genetic information from biospecimens. Inconsistencies make it difficult to interpret which regulations or norms apply, or if applicable regulations or norms are congruent. Tools are necessary to support consistent, expert-informed consent processes and downstream reuse of residual clinical biospecimens and health data by nurse scientists.en-USPublisher PolicyResidual clinical biospecimensHealth dataData sharing and reuseBiospecimen researchNursing researchArticle