Edwards, Paul C.Fantasia, John E.2013-10-022013-10-022007Edwards PC, Fantasia JE. (2007) Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers. Clin Interv Aging. 2(4):509-19.https://hdl.handle.net/1805/3602Abstract: Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as “rede- fining” dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.en-UShyaluronic acidRestylane®Hylaform®injectable dermal fillergranulomaforeign body reactionArticle