Kwon, Jason J.Factora, Tricia D.Dey, ShatovishaKota, Janaiah2019-07-252019-07-252018-12-31Kwon, J. J., Factora, T. D., Dey, S., & Kota, J. (2018). A Systematic Review of miR-29 in Cancer. Molecular therapy oncolytics, 12, 173–194. doi:10.1016/j.omto.2018.12.011https://hdl.handle.net/1805/19960MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29's functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesMicroRNAs (miRNA)non-coding RNAsEukaryotic gene expressionmiR-29OncogeneArticle