Janga, Sarath ChandraEdupuganti, Mohan Mallikarjuna Rao2015-04-232015-04-232014-11Janga, S. C., & Edupuganti, M. M. R. (2014). Systems and Network-Based Approaches for Personalized Medicine. Current Synthetic and Systems Biology. 2 (3). http://dx.doi.org/10.4172/2332-0737.1000e109https://hdl.handle.net/1805/6239Most biological outcomes in a cell arise from a complex interplay between different cellular entities such as proteins, DNA, RNA and metabolites. Therefore, a key challenge for biology in the twenty-first century is to understand the structure and dynamics of the complex web of interactions in a cell that contribute to its proper functioning. Recent years have seen a surge in the amount of “omics” data and an integration of several disciplines which has influenced all areas of life sciences, from molecular biology to medicine. With the emergence of a number of sophisticated tools and technologies as a result of genomics revolution, we are now in a position to view the molecular aspects of diseases at a systems level by incorporating various cellular entities into a network framework. Such systems/network-based approaches are not only enabling us to develop models of disease and wellness in a population but also contributing to our efforts to reverse engineer the molecular networks corresponding to disease states by perturbing using drug cocktails. These multi-scale personalized medicine approaches are likely to significantly re-shape the health care industry in the coming decades and decrease the division that we currently see between medicine and other biotechnology disciplines.en-USAttribution 3.0 United Statessystems biologynetwork pharmacologydrug discoveryArticle