Dobbertin, MatthewBlair, Karina S.Aloi, JosephBajaj, SahilBashford-Largo, JohannahMathur, AvantikaZhang, RuCarollo, ErinSchwartz, AmandaElowsky, JaimieRingle, J. L.Tyler, PatrickBlair, R. James2024-05-232024-05-232024-01-23Dobbertin M, Blair KS, Aloi J, et al. Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care [published correction appears in Transl Psychiatry. 2024 Feb 19;14(1):100]. Transl Psychiatry. 2024;14(1):54. Published 2024 Jan 23. doi:10.1038/s41398-023-02723-9https://hdl.handle.net/1805/40962Background: Suicide is the second leading cause of death for adolescents in the United States. However, relatively little is known about the forms of atypical neuro-cognitive function that are correlates of suicidal ideation (SI). One form of cognitive/affective function that, when dysfunctional, is associated with SI is emotion regulation. However, very little work has investigated the neural correlates of emotion dysregulation in adolescents with SI. Methods: Participants (N = 111 aged 12-18, 32 females, 31 [27.9%] reporting SI) were recruited shortly after their arrival at a residential care facility where they had been referred for behavioral and mental health problems. Daily reports of SI were collected during the participants' first 90-days in residential care. Participants were presented with a task-fMRI measure of emotion regulation - the Affective Number Stroop task shortly after recruitment. Participants were divided into two groups matched for age, sex and IQ based on whether they demonstrated SI. Results: Participants who demonstrated SI showed increased recruitment of regions including dorsomedial prefrontal cortex/supplemental motor area and parietal cortex during task (congruent and incongruent) relative to view trials in the context of emotional relative to neutral distracters. Conclusions: Participants with SI showed increased recruitment of regions implicated in executive control during the performance of a task indexing automatic emotion regulation. Such data might suggest a relative inefficiency in the recruitment of these regions in individuals with SI.en-USAttribution 4.0 InternationalPredictive markersHuman behaviourEmotional regulationExecutive functionSuicidal ideationArticle