Tirkes, TemelFogel, Evan L.Sherman, StuartLin, ChenSwensson, JordanAkisik, FatihSandrasegaran, Kumaresan2017-05-172017-05-172017-02Tirkes, T., Fogel, E. L., Sherman, S., Lin, C., Swensson, J., Akisik, F., & Sandrasegaran, K. (2017). Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis. Abdominal Radiology, 42(2), 544–551. https://doi.org/10.1007/s00261-016-0917-2https://hdl.handle.net/1805/12564Purpose To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. Methods A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST. Signal intensity ratio of pancreas (SIR), fat signal fraction, pancreatograms findings, and grade of duodenal filling were recorded on S-MRCP by two blinded radiologists. Results There was a significant difference in the signal intensity ratio of the pancreas to spleen (SIRp/s) between the normal and low bicarbonate groups (p < 0.0001). A significant positive correlation was found between pancreatic fluid bicarbonate level and SIRp/s (p < 0.0001). SIRp/s of 1.2 yielded sensitivity of 77% and specificity of 83% for detection of pancreatic exocrine dysfunction (AUC: 0.89). Conclusion T1-weighted MR signal of the pancreas has a high sensitivity and specificity for the detection of parenchymal abnormalities related to exocrine dysfunction and can therefore be helpful in evaluation of suspected early CP.enPublisher Policychronic pancreatitissecretin simulation testmagnetic resonance imagingArticle