Cannon, AnthonyPajulas, AbigailKaplan, Mark H.Zhang, Jilu2024-08-232024-08-232023Cannon A, Pajulas A, Kaplan MH, Zhang J. The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment. J Interferon Cytokine Res. 2023;43(6):229-245. doi:10.1089/jir.2023.0035https://hdl.handle.net/1805/42902Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central role in pathologies such as allergic asthma, immunity to parasitic infection, and autoimmunity. More recently, IL-9 has garnered considerable attention in tumor immunity. Historically, IL-9 has been associated with a protumor function in hematological malignancies and an antitumor function in solid malignancies. However, recent discoveries of the dynamic role of IL-9 in cancer progression suggest that IL-9 can act as both a pro- or antitumor factor in various hematological and solid malignancies. This review summarizes IL-9-dependent control of tumor growth, regulation, and therapeutic applicability of IL-9 blockade and IL-9-producing cells in cancer.en-USPublisher PolicyIL-9CancerCytokineImmunotherapyTumor immunityTumor microenvironmentArticle