Lewis, Joshua E.Singh, NaveenHolmila, Reetta J.Sumer, Baran D.Williams, Noelle S.Furdui, Cristina M.Kemp, Melissa L.Boothman, David A.2020-03-022020-03-022019-01Lewis, J. E., Singh, N., Holmila, R. J., Sumer, B. D., Williams, N. S., Furdui, C. M., ... & Boothman, D. A. (2019, January). Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses. In Seminars in radiation oncology (Vol. 29, No. 1, pp. 6-15). WB Saunders. 10.1016/j.semradonc.2018.10.0091053-4296https://hdl.handle.net/1805/22203Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy.en-USPublisher PolicyNicotinamide adenine dinucleotide (NAD+)Nicotinamide adenine dinucleotide (NAD+) metabolismRadiation therapyArticle