Kaefer, MartinEugster, Erica2020-07-212020-07-212020-05-03Kaefer, M., & Eugster, E. (2020). Hormonal suppression of mini-puberty in a neonate with mosaic 45X/46XY disorder of sexual development. Urology case reports, 32, 101237. https://doi.org/10.1016/j.eucr.2020.101237https://hdl.handle.net/1805/23306Disorders of Sex Development (DSD) are some of the most controversial and challenging conditions that pediatric urologists treat. This may be especially true in mosaic 45X/46XY DSD, due to the inability to ascertain in the neonatal period which gender identity will best suit a given child with this condition. It has therefore been proposed to forgo any irreversible surgical interventions. In order to address the concern of early testosterone production in a nonsurgical manner we describe a case in which we treat a patient with a GnRH agonist to block the early physiologic rise in testosterone during the neonatal mini-puberty.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalDisorder of sex developmentMini-pubertyGnRH agonistMosaicismTesticleTestosteroneArticle